We found that the CYP26B1 polymorphism AA significantly correlated with the risk of oral cancer (OR = 2.26; 95% CI, 1.35–3.80), and BQ chewers with the AA genotype had a significantly increased risk of oral cancer (OR = 70.04; 95% CI, 13.62–360.11). This evidence concerns the gene CYP26B1 and lip and oral cavity carcinoma.