In favor of a role for systemic rather than intrathecal antibodies, animal experiments have shown that certain regions of the brain, that is, the hippocampus and the hypothalamus, seem to be particularly vulnerable, and it is notable that limbic encephalitis with VGKC-complex (LGI1 and Caspr2) antibodies and anti-NMDAR encephalitis usually start with symptoms originating from the temporal lobe cortex, even though the target antigens are present much more widely in the CNS. The gene discussed is LGI1; the disease is encephalitis.