Most importantly, our studies raise the possibility that targeting androgen/AR by ADT or siRNA may help to select PCa stem/progenitor cells via CCL2/EMT signalling pathways, since more and more evidence supports an interesting phenomenon that cancer cells that have undergone EMT often share similar characteristics with stem/progenitor cells (Gupta et al, 2009). The gene discussed is AR; the disease is posterior cortical atrophy.