Importantly, combined targeting of PCa AR (with AR-siRNA) and anti-CCL2/CCR2 axis (with CCR2atg) notably suppressed the growth of orthotopic TRAMP-C1 tumours (Fig 6C and D, siAR veh vs. siAR CCR2atg, p = 0.018). This evidence concerns the gene CCR2 and neoplasm.