In order to corroborate our findings with the link of AR silencing to CCL2 in other experimental settings, we analysed microarray studies deposited in the public NCBI database (Varambally et al, 2005); (Wang et al, 2007), we took advantage of these gene-profiling databases and found increased CCL2 expression in PCa tissues (Supporting Information Fig S8A). Here, AR is linked to posterior cortical atrophy.