Preclinical in vitro data have shown that lenalidomide can enhance ADCC mediated by human NK cells with rituximab (anti-CD20) against lymphoma and chronic lymphocytic leukemia cells [18–20], with SGN-40 (anti-CD40) against multiple myeloma and chronic lymphocytic leukemia cells [21, 22], and with trastuzumab (anti-HER2/neu) and cetuximab (anti-EGFR) against solid tumor cell lines [23]. Here, ERBB2 is linked to plasma cell myeloma.