STAT3 and T-cell non-Hodgkin lymphoma: The potential importance of STAT3 pathway activation in suppressing NK cell cytotoxicity is supported by experiments showing that NK cells from tumor-bearing mice with induced ablation of STAT3 signaling are more cytotoxic against T cell lymphoma YAC-1 cells, which are NK cell-sensitive, than those from tumor-bearing mice with wild-type STAT3 [6].