MITF and melanoma: An LFV in the melanocyte master regulator microphthalmia-associated transcription factor (MITF) increases melanoma risk (OR 2.19, 95% CI 1.41–3.45) and has a large effect in individuals with family history and multiple melanomas (OR 8.37, 95% CI 2.58–23.80) (Yokoyama et al., 2011).