To verify the pro-apoptotic activity of PCAF on HCC cells, we increased the expression of PCAF in another kind of HCC cells with low level of PCAF - HepG2 cell, as shown in Additional file1: Figure S1 A. The percentage of DAPI staining cells in HepG2 cells with high level of PCAF (HepG2 PCAF) was significantly higher than one in HepG2 cells with low level of PCAF (HepG2 Control) (Additional file1: Figure S1 B). Here, KAT2B is linked to hepatocellular carcinoma.