It has been hypothesized that there are greater numbers of individuals in the community with genetically determined gluten-mediated disease than just those with raised levels of TG2 IgA or EMA [1,27], and some patients with biopsy-confirmed CD who are seronegative for TG2 IgA do have raised DGP IgA or IgG levels [28]. Here, CD79A is linked to Cowden disease.