NCS1 and autism spectrum disorder: Moreover, characterisation of a point mutant in human NCS-1 (R102Q) identified in a case of autism spectrum disorder [59] revealed that the mutant had structural changes indicating increased dynamics of residues 169–190 [24] and bound target peptide with higher affinity [44] consistent with the C-terminal pocket no longer being occluded by the C-terminal tail in this mutant.