In this medium-size cohort study of patients with stable coronary heart disease at baseline only few patients homozygous for a loss-of-function variant of the CYP2C19*2, allele, compared to the wild-type carriers, showed a statistically significant higher risk for secondary CVD events during long-term follow-up even after adjustment for covariates. Here, CYP2C19 is linked to coronary artery disorder.