The findings of the current study presented herein agree with these data, collectively supporting the hypothesis that serum FGF21 level is likely involved in the process of CAD; the current study provides novel insights into the contribution of FGF21 being independent of such traditional cardiac risk factors as age, hyperglycemia, hypertension, dyslipidemia, and even NAFLD. The gene discussed is FGF21; the disease is Hyperglycemia.