GSDMA and alopecia: By contrast, the phenotype of the TG mice indicates that Gsdma has the same function to regulate epithelial cell proliferation and/or epithelial maintenance as the mouse paralogous gene, Gsdma3. It is notable that the alopecia started to appear only in the progeny obtained by backcrossing of the original TG mice with the mixed genetic background onto the B6 strain.