The PI3K/AKT/mTOR axis is the master negative regulator of autophagy in various cell systems including MM, although constitutively activated in those cells [19-22].To ensure that the PI3K/AKT/mTOR pathway was recruited after AEBS ligand treatment, we used specific PI3K and mTOR inhibitors in combination with RU 39411 and PBPE. Here, MTOR is linked to Miyoshi myopathy.