The PI3K/AKT/mTOR axis is the master negative regulator of autophagy in various cell systems including MM, although constitutively activated in those cells [19-22].To ensure that the PI3K/AKT/mTOR pathway was recruited after AEBS ligand treatment, we used specific PI3K and mTOR inhibitors in combination with RU 39411 and PBPE. This evidence concerns the gene AKT1 and Miyoshi myopathy.