The AEBS/ChEH binds various structural classes of ligands: SERMs, several σ receptor ligands, polyunsaturated fatty acids and ring B oxysterols but neither estrogens nor the SERDs such as RU 58688 and fulvestrant [13].We have previously reported that AEBS-binding by Tam or OHT induces MCF7 breast cancer (BC) cell apoptosis and autophagy through the alteration of cholesterol metabolism [14]. This evidence concerns the gene STIM1 and breast cancer.