The rheostat model proposed above can further be supported by the study reported higher BIM expression in prostate and breast cancer but BIM was phosphorylated at Ser69 and Ser87, which are thought to neutralize the apoptotic function of BIM, furthermore, BIM was sequestered by pro-survival BCL-xL and MCL-1 [60]. The gene discussed is BCL2L1; the disease is breast carcinoma.