The data we obtained on mIGF-1 transgenic mice are in agreement with these previous findings and support the hypothesis that IGF-1 and p53 are crucial players of muscle sarcopenia, as these animals that were previously reported to maintain the integrity of muscle mass and strength during aging without accumulation of body fat [18], resulted to have little or no expression of both Plin2 and p53. This evidence concerns the gene TP53 and sarcopenia.