Because IL-1R signaling is known to activate the TACE-EGFR cascade [42], [43] and to stimulate IL-8 production [44], we reasoned that exaggerated IL-8 production in CF airway epithelial cells could occur via IL-1R-dependent activation of the TACE-EGFR cascade. The gene discussed is IL1R1; the disease is cystic fibrosis.