In cystic fibrosis (CF), a disease caused by mutations in the CF transmembrane conductance regulator (CFTR) protein [2], [3], exaggerated airway epithelial IL-8 production [4]–[6] leads to persistent neutrophilic inflammation, a serious and presently untreated feature of CF airway disease [7]. The gene discussed is CFTR; the disease is cystic fibrosis.