CRP and systemic inflammatory response syndrome: However, given that there were no statistical correlations between plasma mtDNA and WBC, as well as CRP, this result may indicate that the original sources or the mechanisms implicated in the release of mtDNA are different from those responsible for WBC or CRP; thus, in this sense, the measurement of circulating plasma mtDNA may complement WBC and CRP in the prediction of post-traumatic SIRS.