TCF7L2 and myeloid sarcoma: In tissue samples from four MS patients (patient no. 2, 6, 26 and 30, see Table 1) high numbers of TCF7L2 positive cells were detected (PPWM (n=1), actively demyelinating (n = 1) or remyelinating (n = 2) lesion areas) (Figure 5A); however no obvious differences with respect to numbers of T cells, macrophages or NOGOA positive oligodendrocytes were found (Figure 4A to C).