ITGB5 and ovarian carcinoma: We thus chose the SKOV-3 cell line as a representative example of a large proportion of the ovarian cancer cell lines (medium-to-high MFGE8, detectable ITGB3 and ITGB5), and one susceptible to respond to MFGE8 since it expressed the known receptors for MFGE8, to develop the functional in vitro assays.