TMEM201 and arthritic joint disease: The pathogenic relationship between extraintestinal manifestations and intestinal inflammation in IBD is poorly understood, partly because very few experimental models of intestinal inflammation display extraintestinal disease, (a small percentage of SAMP1/YitFc mice, which develop spontaneous Crohn’s-like ileitis with 100% penetrance, also develop perianal disease, and the HLA-B27 transgenic colitic rat displays arthritis) [32,33].