TNF and severe combined immunodeficiency: In addition, secretion of IL-2 and TNFα were also higher (IL-2: TNFi∆ARE/i∆ARE → SCID = 303 ± 64.8 pg/ml vs. wt → SCID mice = 40.4 ± 1.7 pg/ml, P<0.01; TNFα: TNFi∆ARE/i∆ARE → SCID = 1,672 ± 343 pg/ml vs. wt → SCID mice = 194 ± 13.5 pg/ml, P<0.01).