IGHG3 and cancer: The searching results indicated that 5 of these 9 candidate markers were found to have known roles associated with cancer development, and the details were shown as follows: PDIA6 (protein disulfide isomerase family A, member 6)[41], [42], MEG3 (maternally expressed 3)[43], [44], SDCCAG3 (serologically defined colon cancer antigen 3)[45], [46], IGHG1 (Immunoglobulin heavy constant gamma 1)[47]–[49], IGHG3 (Immunoglobulin heavy constant gamma 3)[50]–[52], NADH dehydrogenase 1, BAC RP11-484D18, Clone CH507-528H12 on chromosome 21 and Clone RP11-413M3 on chromosome 9 (Table 3).