Growing evidences from the Ramipril Efficacy in Nephropathy (REIN) study [22], the Reduction of End Points in NIDDM with Angiotensin II antagonist Losartan (RENAAL) study [23] and others have showed that the level of proteinuria is a predictor of CKD progression, irrespective of blood pressure control and treatment randomization. This evidence concerns the gene AGT and chronic kidney disease.