Until recently, only one Caucasian study suggested that the BCL2 rs1462129 C and rs2551402 A allele were associated with increased lung cancer risk (661 Cases and 959 controls), but these associations were not replicated in a larger Caucasian population of 1154 lung cancer cases and 1073 controls, although the P-value in the result of pooled dataset reached the significance level. This evidence concerns the gene BCL2 and lung cancer.