A preliminary study [18] demonstrated that Th1 cells are the most important T-cell subgroup in the pathogenesis of CVB-induced myocarditis; the Th1 cells protected the myocardium from injury mainly by secreting the cytokine IFN-γ, which is associated with the negative regulation of RORγt, the transcription factor of the Th17 cell subtype [19], [20]. This evidence concerns the gene IFNG and myocarditis.