It is noteworthy that while the overexpression of Wnt7a ameliorates myopathy [63] and our results show that the pro-regenerative phenotype observed as a result of MMP-9 inhibition is accompanied by a reduction in the non-canonical Wnt pathway, these findings do not necessarily oppose each other because activation of Wnt7a has been shown to cause muscle hypertrophy in mdx mice [63] whereas our studies have revealed that the inhibition of MMP-9 has no preservative effect against muscle injury but acts by expediting muscle regeneration. Here, MMP9 is linked to myopathy.