Constitutive MALT1 activity may also be a driving force for the growth of B-cell lymphomas of the mucosa-associated lymphoid tissue (MALT lymphomas), which frequently have a chromosomal translocation that leads to the formation of an oncogenic fusion protein of MALT1 with the apoptosis inhibitor c-IAP2 [30]. This evidence concerns the gene MALT1 and MALT lymphoma.