Several genes that are involved in mucosal protection and immunity, such as Cxcl2 and IL-12A, retain levels of expression that are comparable to those observed in WT C57BL/6 mice and Lcn2, a gene that has been associated with gut inflammation [46], was detected at higher levels in Casp1−/− mice (Fig. S2 C). Here, CASP1 is linked to inflammation.