Most recently, we found that ERα binding, and subsequent activation of phosphatidylinositide 3-kinase (PI3k) and protein kinase B (Akt) signaling pathways, plays a role in EGCG-elicited APP α-secretase processing in murine neuroblastoma cells overexpressing the Swedish mutant form of APP (N2a/APPsw cells) [18]. The gene discussed is AKT1; the disease is neuroblastoma.