These samples were further subdivided using the tumor, node, metastasis (TNM) scoring system and showed that the relative levels of WISP1 were significantly higher in patients with grades pT2, pT2 and pT3 compared to either NL or to patients that were lymph node and seminal vesicle positive (LN+/SV+) (Figure 1C). This evidence concerns the gene CCN4 and neoplasm.