CCN4 and cancer: Since its original identification, WISP1 has been found in a variety of cancers, including esophageal squamous cell carcinoma [12], chondrosarcoma [13], breast carcinoma [14], [15], neurofibromatosis type I [16], colorectal carcinoma [17], Lewis lung carcinoma [18], invasive cholangiocarcinoma, scirrhous gastric carcinoma [19] and endometrial endometriod adenocarcinoma [20].