CCN4 and neoplasm: To determine the location and WISP1 expression in the invading tumor and its proximity relative to the osteoclasts that were actively resorbing the bone tissue in this lytic tumor model we prepared sections through a tumor in the jaw and stained them for Tartrate-resistant acid phosphatase (TRAP) an enzyme enriched in the osteoclast and for WISP1 by immunohistochemistry.