EGF and glioblastoma: Recently, there has been increased interest in the EGFR status of GBM and EGFR-targeted therapy, including EGFRvIII (a mutated variant of EGFR with continuous autoactivation without EGF found frequently (20–30%) in GBMs) targeted therapy, which has been the subject of several studies relating imaging and EGFR status, especially using perfusion MR images [13], [20].