STAT6 and congenital primary aphakia: Similarly to the cytokine loci, the locations of some differentially methylated regions associated with aggression coincided with the location of regulatory regions such as the promoters (as defined earlier −2000 bp to 1000 bp of TSS) of both STAT6 isoforms as well as in the NFkB1 short transcript (p50) that were more methylated in the CPA group (Table 2).