STAT6 and congenital primary aphakia: We found that most of the differentially methylated regions associated with CPA identified in NFkB1 and STAT6 loci in both cell types were located within DNase hypersensitive clusters, transcription factors binding sites and H3K4Me1, H3K4Me3 and H3K27Ac peaks, supporting a regulatory role for these regions (Table 2 and Figures S4 and S6).