Indeed, previous studies have shown that the N-myc amplified neuroblastoma cell lines (SMS-KCNR, LA1-55N and SK-N-JD) were more sensitive to HDAC inhibitors (MS-27-275 and TSA) than the unamplified neuroblastoma cell line (SK-N-AS) [21], [38]. The gene discussed is MYCN; the disease is neuroblastoma.