UCP1 and cancer: However, an increased tendency toward adipogenic differentiation, which was indicated by enhanced lipid accumulation (Fig. 3A, Fig. S1A) and higher expression of adipocyte-specific markers adiponectin (Adipoq) and uncoupling protein 1 (UCP1) (Fig. 3B) was found in all three cancer-associated 3A6 derivatives with supreme induction seen in 3A6PC3 when compared with normal 3A6RWV or parental 3A6 cells.