Diet interventions (HC and HCE) reduced founder male body weight (HC −2.37±0.79 g and HCE −3.19±0.75 g), levels of adiposity (p<0.01), serum cholesterol (p<0.05), serum leptin (p<0.05), increased lean mass (p<0.05) and improved glucose tolerance (p<0.05) but maintained insulin resistance as measured by AAC compared with HH males (Table S3 and Table S4). The gene discussed is LEP; the disease is Insulin resistance.