The importance of genetic and epigenetic changes in the aetiology and pathogenesis of NAFLD has been increasingly recognized and a large number of SNPs related to NAFLD has been documented by candidate gene studies [18]–[21], [33] To our knowledge, this is the first study providing evidence of an association between APPL1 and APPL2 genetic variants and NAFLD in humans. This evidence concerns the gene APPL2 and metabolic dysfunction-associated steatotic liver disease.