When the most common allele combination consisting of the 2 major alleles G-G considered as reference, as expected the all-minor-allele combination CA was associated with an increased risk of NAFLD (OD = 2.50 95% CI 1.45–4.32; p<0.0009) even after adjustment for age, sex, BMI, HOMA IR, triglycerides and adiponectin levels. Here, ADIPOQ is linked to metabolic dysfunction-associated steatotic liver disease.