Comparing the different grading of hepatic steatosis among the three genotype groups there was an increased frequency of severe steatosis in NAFLD individuals with APPL1-CC genotype; a trend for individuals with APPL2 AA genotype to have an higher frequency of severe steatosis was also found; the differences however did not reach statistical significance (Figure 1). Here, APPL2 is linked to metabolic dysfunction-associated steatotic liver disease.