A logistic regression analysis revealed that individuals with at least one copy of the rs4640525 C allele and rs11112412 APPL2 A allele had a 2.17 (95% CI: 1.27–3.711; P = 0.004) and 1.96 (95% CI: 1.0008–3.83; P = 0.01) fold increased risk for severe steatosis respectively. This evidence concerns the gene APPL2 and steatosis.