APPL1 and Hepatic steatosis: In agreement, in our study both higher rs4640525-C and rs11112412-A NAFLD risk alleles have been found associated with higher plasma ALT levels and a more severe hepatic steatosis grade.The effect found was independent of plasma adiponectin level underlining that, despite normal or high adiponectin levels, an impaired post receptor signalling due to APPL1/APPL2 SNPS may alter adiponectin efficiency and activity.