APPL1 and metabolic dysfunction-associated steatotic liver disease: The importance of genetic and epigenetic changes in the aetiology and pathogenesis of NAFLD has been increasingly recognized and a large number of SNPs related to NAFLD has been documented by candidate gene studies [18]–[21], [33] To our knowledge, this is the first study providing evidence of an association between APPL1 and APPL2 genetic variants and NAFLD in humans.