IK and neoplasm: IK also exhibits a tumor suppressor function in lymphocyte precursors, which has been attributed in part to its ability to repress expression of oncogenic genes via chromatin remodeling in association with the SWI/SNF remodeling complex and recruitment of potentially oncogenic proliferation-promoting genes to pericentromeric heterochromatin (PC-HC) [10]–[12], [26], [30].