SPTLC2 and dermatitis: In fact, mRNA expression levels of 3-Hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2), involved in cholesterol synthesis, of serine palmitoyltransferase 2 (Sptlc2), UDP-glucose ceramide glucosyltransferase (Ugcg), both catalyzing the synthesis of ceramides and glycosyl-ceramides, and of alkaline ceramidase 1 (Acer1), which is responsible for ceramide degradation, were significantly elevated in the skin of mice with allergen-induced dermatitis and/or solely systemic OVA sensitization (Table 2).