However, the recent discovery of SLC41A1 as a Na+/Mg2+ exchanger (NME; Mg2+-efflux system) [20] and its localization within the newly identified PD locus PARK16[21], [22], [23], [24] makes this protein an interesting candidate to explain the involvement of disturbed intracellular Mg2+ homeostasis in PD pathophysiology. Here, SLC41A1 is linked to Parkinson disease.