SLC41A1 and Parkinson disease: Here, we demonstrate that the substitution p.A350V potentially associated with PD is a gain-of-function mutation that enhances a core function of SLC41A1, namely Na+-dependent Mg2+ efflux by 69±10% under our experimental conditions (10-minute incubation in high-Na+ (145 mM) and completely Mg2+-free medium).