Furthermore, PD-relevant genes with a recessive pattern of inheritance (parkin/PARK2, PINK1, and DJ-1/PARK7) are all related to mitochondria dysfunction and oxidative stress making it possible that defects in these genes and disturbances of IMH intervene in these pathways to induce nigral mitochondrial cytopathy [67]. Here, PRKN is linked to inborn mitochondrial myopathy.