The association analysis between HVEM haplotypes and breast cancer clinicopathologic features found that haplotype ACGCGG (rs2281852-rs1886730-rs2234163-rs11573979-rs2234165-rs2234167) was occurred more frequently in lymph node metastasis, PR and CerbB-2 negative cases (P = 0.0187, P = 0.043 and P = 0.0383, respectively). The gene discussed is PGR; the disease is breast cancer.