CDKN2A and cancer: The site is near the major senescence and cancer associated genes CDKN2A and CDKN2B coding for P16INK4A, P15INK4B and P19ARF, but actually maps to a non-protein coding segment coding for the long RNA called ANRIL, which has since been shown to interact in cis, via γ-interferon and possibly via common sense and anti-sense activation of their shared promoter region, with P16INK4A [12].