Previous work has demonstrated that the deletion of NF-κB1 or NF-κB2 proteins can have different effects on gastrointestinal disease processes, including differences in the ability to clear Trichuris muris parasites.23 Classical pathway NF-κB signaling has become one of the most studied pathways in inflammation-associated cancer; however, the function of specific NF-κB proteins has been relatively little studied in this context. Here, NFKB1 is linked to cancer.