IGHE and allergic disease: In one study, a higher level of IgE sensitization to food allergens was observed in patients with eosinophilic esophagitis alone compared to patients with both pathologies, and this led the authors to hypothesize that patients with both pathologies have elevated esophageal eosinophils for reasons different from allergy, with a significant clinical and histological remission on gluten-free diet [22].