Specifically, they characterize the first receptor for any GH 18 moiety by demonstrating that the chitinase-like protein (CLP) Chi3l1 binds to, signals, and regulates oxidant injury, apoptosis, pyroptosis, inflammasome activation, pathogen responses, melanoma metastasis, and TGF-β1 via IL-13Rα2. The gene discussed is CHI3L1; the disease is melanoma.