TGFB1 and melanoma: Recent studies by the Strober group also highlighted the importance of IL-13Rα2 in the progression of malignant melanoma, where its activation by IL-13 caused TGF-β1 elaboration, which inhibited tumor immune surveillance and favored tumor growth (Fichtner-Feigl et al., 2008b; Strober et al., 2009).