CHI3L1 and melanoma: In accord with the studies of Strober et al. (Fichtner-Feigl et al., 2008b; Strober et al., 2009), these meta-static responses were associated with modest increases in the levels of TGF-β1 in WT mice and significantly enhanced levels of total and activated TGF-β1 in melanoma-challenged YKL-40 Tg animals (Figures 7C and 7D).