Furthermore, several signaling pathways involved in angiogenesis (cyclooxygenase 2, vascular endothelial growth factor A), cellular regulation (MKI67 etc.), epidermal growth factor (EGF receptor, pAKT, etc.)and Sonic hedgehog–Gli pathways are modified in plexiform neurofibromas associated with transformation [25]. This evidence concerns the gene VEGFA and plexiform neurofibroma.