ESR1 and neoplasm: The K-M plots (Figures 9 to 12) depict DFS experience for patients whose tumours under central review had ER or PgR assay results categorized by their Z-scores to be multiple SDs above or below the mean: greater to or equal to 1 SD below mean, less than 1SD below the mean, less than or equal to 1 SD above the mean, and greater than 1 SD above the mean.