Other networks significantly enriched also related to a further network in connective tissue disorders that contained genes including collagens COL10A1, COL11A1 and COL2A1 plus a disintegrin and metalloproteinase with thrombospondin motifs-2 (ADAMTS-2) and fibulin-1 (FBLN1) (Figure 3B). This evidence concerns the gene ADAMTS2 and connective tissue disorder.