COL16A1 and connective tissue disorder: According to the top-scoring network, the differentially expressed genes were from connective tissue disorders, such as collagens COL12A1, COL16A1, COL1A1, and COL25A1 plus leucine-rich repeat and immunoglobulin domain containing 1 (LINGO), transforming growth factor beta (TGFβ)-induced 68 kDa and coclin (COCH) (Figure 3A).