In our case, the patient was predisposed to a prothrombotic state because of severe hypoalbuminemia and hypercholesterolemia along with low levels of antithrombin III and protein C. She did not have any other prothrombotic risk factors, nor did she have symptoms which suggest collagen diseases such as systemic lupus erythematosus. Here, SERPINC1 is linked to Hypercholesterolemia.