Salicylic acid has no effect on CaCo-2 (colon carcinoma cells) proliferation under normoxic conditions but increases caspase-3/7 activities and increases phosphorylation of ERK 1/2 under hypoxic conditions: salicylic acid increases caspase-3/7 activities but also decreases cell proliferation but has no effect on ERK 1/2 phosphorylation (116). This evidence concerns the gene CASP3 and colon carcinoma.