Approved biologic agents used in RA include cytokine inhibitors of TNF alpha (adalimumab, etanercept, infliximab, certolizumab pegol, and golimumab), IL-6 receptor (tocilizumab), IL-1 (anakinra), cell depleting agent targeting CD 20 of B cells (rituximab), and costimulation blocker of cytotoxic T lymphocyte antigen-4 (abatacept) [11, 13, 14]. The gene discussed is TNF; the disease is rheumatoid arthritis.