After EA on the Dazhui (DU14) and Baihui (DU20) acupuncture points, the number of ERK-positive striatal cells increased significantly in the cerebral cortex, and ERK protein expression was increased in rats with damaged neurons after cerebral ischemia and reperfusion; therefore, EA can increase ERK pathway activity [44, 45]. The gene discussed is MAPK1; the disease is Cerebral ischemia.