The positive correlation between high MMSE score and the IL-11/IP-10 peaks detected in CFS suggests that up-regulation of these cytokines is an early event in the pathogenesis of AD/FTLD, that is, not observed in the late stages of the disease, implying that the high level of proinflammatory cytokine represents an early and transitory effort of immune cells to restore brain health [105, 107]. Here, CXCL10 is linked to Alzheimer disease.